Evaluation of the relationship between serum estradiol levels on human chorionic gonadotropin administration day and intracytoplasmic sperm injection outcomes: A retrospective population-based study. International journal of reproductive biomedicine BACKGROUND:The correlation between high estradiol (E2) levels induced by controlled ovarian hyperstimulation (COH) and pregnancy is controversial. OBJECTIVE:To assess the effect of serum E2 levels on the day of human chorionic gonadotropin administration on the intracytoplasmic sperm injection (ICSI) outcome. MATERIALS AND METHODS:The current study included 551 participants who had undergone ICSI between May 2014 and May 2016. Based on E2 levels, the individuals aged 37 yr (n = 502) and 37-42 yr (n = 49) were categorized into six and three groups, respectively. ICSI outcomes including the number of retrieved oocytes (NRO), number of embryos (NE), pregnancy rate, and abortion rate were analyzed in both groups. RESULTS:Among participants aged 37 yr, the NRO and NE were 8.69 3.82 and 5.24 2.32, respectively and they had a significant correlation with the E2 level on human chorionic gonadotropin administration day (p 0.001 for both). Among participants aged 37 yr, NRO and NE were 5.18 3.17 and 3.40 2.23, respectively, and the NRO (p 0.001), NE (p 0.001), pregnancy rate (p 0.001), abortion rate (p = 0.007), and the number of grade A and B embryos (p = 0.003) had a significant association with the E2 level. CONCLUSION:COH is a costly procedure that may have negative effects on endometrial receptivity. Thus, in order to prevent these effects and also to reduce the costs of COH, we recommend gaining optimum number of oocytes rather than maximum number during the procedure. 10.18502/ijrm.v19i7.9470

Serum human chorionic gonadotropin levels on the day before oocyte retrieval do not correlate with oocyte maturity. Levy Gary,Hill Micah J,Ramirez Christina,Plowden Torrie,Pilgrim Justin,Howard Robin S,Segars James H,Csokmay John Fertility and sterility OBJECTIVE:To evaluate the correlation of preretrieval quantitative serum hCG level with oocyte maturity. DESIGN:Retrospective cohort study. SETTING:Military assisted reproductive technology (ART) program. PATIENT(S):Fresh autologous ART cycles. INTERVENTION(S):Serum hCG level the day before oocyte retrieval. MAIN OUTCOME MEASURE(S):Linear regression was used to correlate serum hCG levels and oocyte maturity rates. Normal oocyte maturity was defined as ≥75% and the Wilcoxon rank sum test was used to compare serum hCG levels in patients with normal and low oocyte maturity. Threshold analysis was performed to determine hCG levels that could predict oocyte maturity. RESULT(S):A total of 468 ART cycles were analyzed. Serum hCG level was not correlated with hCG dose; however, it was negatively correlated with body mass index (BMI). Serum hCG levels did not differ between patients with oocyte maturity of <75% and ≥75%. Serum hCG levels did not correlate with oocyte maturity rates. Receiver operator characteristic and less than efficiency curves failed to demonstrate thresholds at which hCG could predict oocyte maturity. CONCLUSION(S):Serum hCG levels were not correlated with oocyte maturity. Although a positive hCG was reassuring that mature oocytes would be retrieved for most patients, the specific value was not helpful. 10.1016/j.fertnstert.2012.12.053