Primary sacral non-Hodgkin's lymphoma: report of a case and systematic review of literature. World journal of surgical oncology INTRODUCTION:Isolated primary sacral diffuse large B cell non-Hodgkin's lymphoma is a very rare entity, and only 11 cases have been reported previously. CASE PRESENTATION:A 36-year-old man was referred with low backache and radiculopathy pain with a clinico-radiological and cytological diagnosis of sacral metastasis. Histopathological examination and immunohistochemistry of image-guided tissue core biopsy from the sacral mass confirmed it as high-grade diffuse large B cell lymphoma (DLBCL). With normal blood counts and bone marrow, and no lesions elsewhere on imaging, he was staged IAE and received 6 cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) regimen chemotherapy followed by radiotherapy. The patient has completed a 3-year follow-up and is doing well with yearly imaging showing no evidence of active disease or recurrence. CONCLUSIONS:The case shows the importance of an image-guided core biopsy and immunohistochemistry over a fine needle aspiration cytology in select cases as it can alter the treatment and outcome in patients. Because of rarity, the treatment and prognosis in primary sacral NHL is not still very clear as it is treated as per the guidelines of treatment of bone lymphoma. 10.1186/s12957-021-02153-1

Primary sacral lymphoma: a case report and review of the literature. Nayil Khursheed,Makhdoomi Rumana,Ramzan Altaf,Malik Rayees,Alam Shafiq,Wani Abrar,Chhiber Sarbjit Turkish neurosurgery AIM:Primary sacral lymphoma is rare. It usually presents in elderly males as low back ache and radiculopathy. CASE REPORT:We hereby report a case of primary sacral lymphoma in a 53-year-old male who presented with low back pain. Imaging showed a sacral lesion which on histopathology proved to be a non-Hodgkin's lymphoma of B cell lineage. MATERIAL AND METHODS:The case is presented for its rarity and for the reason that it mimicked a primary bone tumor. Its recognition is important because it has an excellent prognosis. CONCLUSION:Primary sacral epidural lymphoma should be considered in the differential diagnosis of a sacral mass. 10.5137/1019-5149.JTN .3001-10.1