[Clinicomorphological observation of bronchioloalveolar carcinoma of the lung].
Vasin V A,Mnikhovich M V,Vasin I V,Snegur S V
Arkhiv patologii
The authors analyze rare lung diseases and describe a clinicomorphological case of bronioloalveolar carcinoma of the lung as one of rare bronchopulmonary diseases. According to the WHO histological classification (1999), the tumor is adenocarcinoma that is represented solely by bronchioloalveolar vegetations as a monolayer of the cells lining the walls of pre-existing alveoles without invasion of the stroma, vessels, and pleura. In 1876 Mallaser first described this rare disease in cloven-hoofed animals (Artiodactyla) in Scandinavian countries. Subsequently cases of this disease were also described in human beings.
Lepidic predominant adenocarcinoma with aerogenous spread of mucin in a young patient -- a case report.
Nguyen Elise,Hakimi Matthew,Chavoshan Bahman,Stringer William,French Samuel W
Experimental and molecular pathology
We present a unique case of a 26 year-old female non-smoker who expired following treatment for presumed pneumonias. At autopsy, lepidic predominant adenocarcinoma with aerogenous spread of mucin without evidence of invasion, a rare diagnosis that previously would have fallen under the umbrella of "bronchioloalveolar carcinoma," was found. Histopathology showed mucin-secreting neoplastic cells lining the alveolar walls, as well as exfoliated and dense aggregates of mucinous debris filling the alveoli. The immediate cause of death was respiratory failure, most likely due to the significant amount of tumor-produced mucin that filled the alveolar spaces, which literally drowned the patient.
10.1016/j.yexmp.2014.04.005
Typical presentation of pulmonary lepidic adenocarcinoma: a rare case report.
Azzeddine Rajae,Rhorfi Ismail Abderahmani,Zegmout Adil,Souhi Hicham,Elouazzani Hanane,Abid Ahmed,Chahdi Hafsa,Tbouda Mohamed
The Pan African medical journal
Bronchioloalveolar carcinoma (BAC) is a rare subtype of adenocarcinoma of lung with distinct features and distinctive characteristics. It accounts approximately for 4% of lung cancers. In the following study we report a rare observation of a 50 years old female with a clinical, radiological and histological presentation, which is typical of an invasive mucinous lepidic adenocarcinoma formerly named BAC.
10.11604/pamj.2020.36.11.22660
Clinical characteristics of patients with bronchioloalveolar carcinoma: a retrospective study of 44 cases.
Dirican Nigar,Baysak Aysegul,Cok Gursel,Goksel Tuncay,Aysan Tulin
Asian Pacific journal of cancer prevention : APJCP
BACKGROUND:Bronchioloalveolar carcinoma (BAC) is considered a subtype of adenocarcinoma of the lung. Recently BAC has been variously termed adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant invasive adenocarcinoma, and invasive mucinous adenocarcinoma. The aim of the study was to analyze and detect prognostic factors of patients with BAC over a 7-year period. MATERIALS AND METHODS:This retrospective single-center study included 44 patients with BAC. The impact on survival of fifteen variables (gender, age, smoking status, cough, dyspnea, hemoptysis, fever, chest pain, sputum, metastasis number, Karnofsky performance status, pT, pN, TNM stage, cytotoxic chemoterapy) were assessed. RESULTS:Median age was 55 years (38-83). Most patients were male (63.6%) and stage IV (59.1%). Twenty-one patients (47.7%) received cytotoxic chemotherapy (platinum-based regimens) for metastatic disease. Objective response rate was 33.3% (4 partial, 3 complete responses). Stable disease was observed in nine in patients (42.8%). Disease progression was noted in 5 (23.8%). The median OS for all patients was 12 months (95%CI, 2.08-22.9 months). Independent predictors for overall survival were: Karnofsky performance status (HR:3.30, p 0.009), pN (HR:3.81, p 0.018), TNM stage (HR:6.49, p 0.012) and hemoptysis (HR:2.31, p 0.046). CONCLUSIONS:Karnofsky performance status, pN, TNM stage and hemoptysis appear to have significant impact on predicting patient survival in cases of BAC.
10.7314/apjcp.2013.14.7.4365